The benefits of plant polyphenols are well known to health enthusiasts. These natural plant constituents block oxidative damage that lead to inflammation and accelerated biological aging of tissues.

Recent studies by three separate laboratories have concluded that polyphenols extracted from apples extend life span in laboratory models by up to 12%. Apples and especially their skin, are rich in an array of polyphenols. One particular major bioactive polyphenol, phloridzin, found in the skin of the apple, has been shown to act as a powerful agent against glycation and other destructive processes in the body. Phloridzin also regulates cell to cell signaling and supports healthy glucose levels in those already within normal range by inhibiting the glucose-6-phosphatase enzyme.

Apple polyphenols can slow triglyceride absorption from the intestine by blocking pancreatic lipase, an enzyme specifically required to break down triglyceride fats. Additional research has shown that apple polyphenols can increase the protective antioxidant molecule paraoxonase by as much as 23%, thereby inhibiting dangerous lipid peroxidation and reducing an inflammatory cascade. Along with phloridzin, apples contain chlorogenic acid. Chlorogenic acid supports healthy glucose levels in those whose glucose levels are already within normal range by inhibiting the glucose-6-phosphatase enzyme, and by increasing some cellular mechanisms that are stimulated by insulin in liver cells.

AppleWise Polyphenol Extract is extracted from the highest quality organically grown apples. Each 600 mg vegetable capsule contains 300 milligrams apple polyphenols.

Consumer note: Members taking supplements providing standardized pomegranate and coffee bean extracts, along with antiglycating nutrients like carnosine, benfotiamine and pyridoxal-5-phosphate may be deriving similar benefits as those provided by apple polyphenols.