in the early 1980s, Life Extension® was the first to introduce CoQ10 as
a method to enhance mitochondrial energy production. CoQ10 has since
gained universal scientific recognition for its role in supporting
cellular performance throughout the body.
a major advance in combating cellular aging called PQQ (pyrroloquinoline
quinone) is being
introduced. In an unprecedented breakthrough, researchers have
discovered that PQQ supports mitochondrial biogenesis— the spontaneous
growth of new mitochondria in aging cells!
are the cellular energy generators that supply virtually all the power
your body requires for a healthy life span. An abundance of published
studies underscores the critical importance of the mitochondria to
overall health, especially as we age. Energy-intensive organs like the
heart and brain are dense with mitochondria.
recently, the only natural ways for aging individuals to increase the
number of mitochondria in their bodies were long-term calorie
restriction or exhaustive physical activity— which are difficult or
impractical for most people to implement. PQQ offers a viable
enormous amount of energy generated within the mitochondria exposes
them to constant free radical attack. The resulting mitochondrial decay
is a hallmark of aging. PQQ protects and augments delicate
mitochondrial structures to promote youthful cellular function in three
- Antioxidant power. Like CoQ10, PQQ is
a highly potent antioxidant. Its extraordinary molecular stability
enables it to facilitate thousands of biochemical reactions in the
mitochondria without breaking down, for maximum antioxidant and
- Favorably modulates gene expression. PQQ activates
genes that promote formation of new mitochondria— and beneficially
interacts with genes directly involved in mitochondrial health. These
same genes also support healthy body weight, normal fat and sugar
metabolism, and youthful cellular proliferation.
- Mitochondrial defense. Mitochondria
possess their own DNA, distinct from the DNA contained in the nucleus.
Unfortunately, compared to nuclear DNA, the DNA housed within each
mitochondrion is relatively unprotected. PQQ's antioxidant potency and
favorable gene expression profile act to support mitochondrial defense.
is an essential nutrient, meaning your body cannot make it on its own.
A growing body of research indicates that PQQ's unique nutritional
profile supports heart health and cognitive function— alone and in
combination with CoQ10. This comes as no surprise, given how much
energy these vital organs need.
shows that PQQ supports heart cell function in the presence of free
radicals and promotes blood flow in heart muscle. When taken in
combination with CoQ10, just 20 mg per day of PQQ has been shown to
promote memory, attention, and cognition in maturing individuals.
Extension® has identified a purified, highly potent form of PQQ from
Japan that is produced through a natural fermentation process. The
result is the highest quality PQQ available on the market today.
mg dose of PQQ has also been added to the Mitochondrial
Energy Optimizer and new Mitochondrial Essentials formulas.