Life Extension, SAMe S-Adenosyl-Methionine, 200 mg 50 tablets

Life Extension, SAMe S-Adenosyl-Methionine, 200 mg 50 tablets
Ready To Order?

List Price: $36.00

Our Price: $27.00


Lowest Price Guarantee! Get Extra Discount!

Product Inquiry

Tell a Friend


SAMe (S-adenosyl-methionine)
200 mg, 50 tablets
Item Catalog Number:

SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:
1) Methylation (contributing methyl groups to activate certain molecules).
2) The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)
3) Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals).

In young, healthy people SAMe is well distributed throughout the body as a result of its synthesis from methionine by enzymes using ATP. However, in sickness and in age, system levels may become depleted. Supplementation of the co-factors folate, TMG, vitamins B6 and B12, together with SAMe appears to be an effective method to overcome this deficiency. There is evidence that SAMe may help to synthesize phosphatidylcholine, which keeps cell membranes fluid and is used in the brain to make the neurotransmitter acetylcholine.*

An agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe in year 2002. Their findings show the efficacy of SAMe in helping maintain stable mood and joint function, without any side effects. Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older.*

SAMe (S-adenosyl-methionine) has multi-modal mechanisms of action that are used throughout the body, and especially the liver. In order to perform its detoxification role, the liver performs thousands of complex enzymatic reactions every second.

SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant, glutathione. When liver function is compromised, glutathione is depleted, which leads to free radical damage. In addition, SAMe acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.*

Supplement Facts

Serving Size 2 tablets

Servings Per Container 25

Amount Per Serving


400 mg

Other ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, sodium starch glycolate, glyceryl triacetate, croscarmellose sodium, stearic acid, silica, titanium dioxide, yellow orche.

Dosage and Use

800-1200 mg (4-6 tablets) per day is recommended.


Take in divided doses morning, midday, and late afternoon.


Taking this product with food may avoid gastrointestinal disturbance.


Refrigeration is recommended.


Take folic acid, vitamins B12, and B6 when using SAMe.*


Do not use SAMe with antidepressant medications except under a doctor’s care. At levels above 400 mg daily, SAMe may cause dry mouth, restlessness and gastrointestinal problems. Cutting back on dosage and then increasing it slowly should alleviate these symptoms.


Keep out of reach of children.


Do not exceed recommended dose.


Do not purchase if outer seal is broken or damaged.

- If you have a bad reaction to product discontinue use immediately.

When using nutritional supplements, please inform your physician if your are undergoing treatment for a medical condition or if you are pregnant or lactating.

Product photo may not exactly match the product offered for sale. Please refer to the product description.